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3-Deazaneplanocin A
CAS No. 102052-95-9
3-Deazaneplanocin A ( NSC 617989;3-Deazaneplanocin;DZNep )
Catalog No. M10098 CAS No. 102052-95-9
A highly potent and competitive S-adenosylhomocysteine hydrolase inhibitor with Ki of 0.05 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 112 | Get Quote |
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| 100MG | Get Quote | Get Quote |
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| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product Name3-Deazaneplanocin A
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NoteResearch use only, not for human use.
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Brief DescriptionA highly potent and competitive S-adenosylhomocysteine hydrolase inhibitor with Ki of 0.05 nM.
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DescriptionA highly potent and competitive S-adenosylhomocysteine hydrolase inhibitor with Ki of 0.05 nM, also inhibits histone methyltransferase EZH2; more potent than 3-deazaaristeromycin; induces EZH2 protein depletion, leads to cell death in several cancers and tumors; anticancer or antiviral agent.
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SynonymsNSC 617989;3-Deazaneplanocin;DZNep
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PathwayChromatin/Epigenetic
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TargetHMTase
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RecptorHMTase
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number102052-95-9
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Formula Weight262.26
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Molecular FormulaC12H14N4O3
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESO[C@@H]1[C@H](O)C(CO)=C[C@H]1N2C=NC3=C2C=CN=C3N
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Chemical Name3-Cyclopentene-1,2-diol, 5-(4-amino-1H-imidazo[4,5-c]pyridin-1-yl)-3-(hydroxymethyl)-, (1S,2R,5R)-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Tseng CK, et al. J Med Chem. 1989 Jul;32(7):1442-6.
2. Glazer RI, et al. Biochem Biophys Res Commun. 1986 Mar 13;135(2):688-94.
3. Fiskus W, et al. Blood. 2009 Sep 24;114(13):2733-43.
4. Puppe J, et al. Breast Cancer Res. 2009;11(4):R63.
2. Glazer RI, et al. Biochem Biophys Res Commun. 1986 Mar 13;135(2):688-94.
3. Fiskus W, et al. Blood. 2009 Sep 24;114(13):2733-43.
4. Puppe J, et al. Breast Cancer Res. 2009;11(4):R63.
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